Litsela tse 3 tse thabisang tseo litsebi tsa k'hemistri li hahileng metsoako ka tsona selemong sena
by Bethany Halford
Li-enzyme tse Fetohileng li Hahile Litlamo tsa Biaryl
Sekema se bontshang kopano ya biaryl e kentsweng ke enzyme.
Litsebi tsa lik'hemik'hale li sebelisa limolek'hule tsa biaryl, tse nang le lihlopha tsa aryl tse hokahaneng ka tlamo e le 'ngoe, e le li-chiral ligands, li-block tsa kaho ea thepa, le meriana. Empa ho etsa motif ea biaryl ka likarabelo tse susumelitsoeng ke tšepe, joalo ka li-cross-coupling tsa Suzuki le Negishi, hangata ho hloka mehato e 'maloa ea maiketsetso ho etsa balekane ba ho kopanya. Ho feta moo, likarabelo tsena tse susumelitsoeng ke tšepe lia fokola ha ho etsoa li-biaryl tse kholo. Ka lebaka la bokhoni ba li-enzyme ba ho susumetsa likarabelo, sehlopha se etelletsoeng pele ke Alison RH Narayan oa Univesithi ea Michigan se sebelisitse phetoho e tataisitsoeng ho theha enzyme ea cytochrome P450 e hahang molek'hule ea biaryl ka ho kopanya oxidative ea litlamo tsa carbon-hydrogen tse nkhang hamonate. Enzyme e kopanya limolek'hule tse nkhang hamonate ho etsa stereoisomer e le 'ngoe ho potoloha tlamo e nang le potoloho e sitisitsoeng (e bontšitsoeng). Bafuputsi ba nahana hore mokhoa ona oa biocatalytic e ka ba phetoho ea bohobe le botoro bakeng sa ho etsa libopeho tsa biaryl (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
RESEPI EA LI-AMINE TSA TERTIARY TSE TŠEPISITSOENG LETSOAI LE LENYENYANE
Sekema se bonts'a karabelo e etsang li-amine tse phahameng ho tsoa ho tse ling.
Ho kopanya di-catalyst tsa tšepe tse lapileng dielektrone le di-amine tse nang le dielektrone tse ngata hangata ho bolaya di-catalyst, kahoo di-reagent tsa tshepe di ke ke tsa sebediswa ho haha di-amine tse tharo ho tswa ho di-amine tse tharo. M. Christina White le basebetsi mmoho le yena Univesithing ya Illinois Urbana-Champaign ba ile ba hlokomela hore ba ka kgona ho qoba bothata bona haeba ba ka eketsa dinoko tse nang le letswai risepeng ya bona ya reactant. Ka ho fetola di-amine tse tharo hore e be matswai a ammonium, ditsebi tsa khemistri di fumane hore di ka sebetsana le metswako ena ka di-olefin tse qetellang, oxidant, le palladium sulfoxide catalyst ho theha di-amine tse ngata tse tharo tse nang le dihlopha tse fapaneng tse sebetsang (mohlala o bontshitswe). ditsebi tsa khemistri di sebedisitse karabelo ho etsa meriana ya antipsychotic Abilify le Semap le ho fetola meriana e teng e leng di-amine tse tharo, jwalo ka antidepressant Prozac, hore e be di-amine tse tharo, ho bontsha kamoo ditsebi tsa khemistri di ka etsang meriana e metjha ho tswa ho tse teng (Science 2022, DOI: 10.1126/science.abn8382).
AZAARENES E ILE EA KOETLISOA KA KHABONE
Sekema se bontsha quinoline N-oxide e fetotsweng N-acylindole.
Selemong sena litsebi tsa k'hemistri li ekelitse pokellong ea ho hlophisa limolek'hule, e leng litšusumetso tse etsang liphetoho lipheletsong tsa limolek'hule tse rarahaneng. Mohlala o mong, bafuputsi ba hlahisitse phetoho e sebelisang leseli le asiti ho khaola khabone e le 'ngoe ho tsoa ho azaarenes tse nang le litho tse tšeletseng ho li-N-oxide tsa quinoline ho theha li-N-acylidole tse nang le mehele e nang le litho tse hlano (mohlala o bontšitsoeng). Karabelo, e ntlafalitsoeng ke litsebi tsa k'hemistri sehlopheng sa Mark D. Levin Univesithing ea Chicago, e thehiloe karabelong e neng e kenyelletsa lebone la mercury, le ileng la tima maqhubu a mangata a khanya. Levin le basebetsi-'moho le eena ba fumane hore ho sebelisa diode e ntšang leseli e ntšang leseli ho 390 nm ho ba file taolo e betere mme ha ba lumella ho etsa karabelo e akaretsang bakeng sa li-N-oxide tsa quinoline. Karabelo e ncha e fa baetsi ba limolek'hule mokhoa oa ho nchafatsa lipheletsong tsa metsoako e rarahaneng 'me e ka thusa litsebi tsa k'hemistri tsa meriana tse batlang ho atolosa lilaebrari tsa bona tsa bakhethoa ba lithethefatsi (Science 2022, DOI: 10.1126/science.abo4282).
Nako ea poso: Tshitwe-19-2022