Litsela tse 3 tse khahlisang tseo litsebi tsa k'hemistri li thehileng metsoako selemong sena
ka Bethany Halford
LITLHAKISO TSA LI-ENNYMES E HAHILE BIARYL BOND
Leano le bonts'ang khokahanyo ea enzyme-catalyzed biaryl.
Litsebi tsa k'hemistri li sebelisa limolek'hule tsa biaryl, tse nang le lihlopha tsa aryl tse kopantsoeng ka tlamo e le 'ngoe, joalo ka li-chiral ligands, li-block tsa thepa ea ho haha, le meriana.Empa ho etsa "biaryl motif" ka ts'ebetso e entsoeng ka tšepe, joalo ka Suzuki le Negishi cross-couplings, hangata ho hloka mehato e 'maloa ea maiketsetso ho etsa balekane.Ho feta moo, liketso tsena tse entsoeng ka tšepe lia fokola ha li etsa li-biaryl tse ngata.E susumetsoa ke bokhoni ba li-enzyme ba ho susumetsa maikutlo, sehlopha se etelletsoeng pele ke Alison RH Narayan oa Univesithi ea Michigan se sebelisitse khopolo ea ho iphetola ha lintho ho theha cytochrome P450 enzyme e hahang molek'hule ea biaryl ka ho kopanya oxidative ea li-bond tsa carbon-hydrogen tse nkhang hamonate.Enzyme e kopanya limolek'hule tse nkhang hamonate ho etsa stereoisomer e le 'ngoe ho pota-pota tlamahano e nang le tšitiso e sitisang (e bontšitsoeng).Bafuputsi ba nahana hore mokhoa ona oa biocatalytic o ka fetoha phetoho ea bohobe le botoro bakeng sa ho etsa li-biaryl bond (Nature 2022, DOI: 10.1038 / s41586-021-04365-7).
RECIPE BAKENG SA TERTIARY AMINES E TŠEHETSE KA LETSWAI LE LENYENYANE
Scheme e bonts'a karabelo e etsang li-amine tsa thuto e phahameng ho tsoa ho tsa bobeli.
Ho kopanya li-catalyst tsa tšepe tse lapileng elektronike le li-amine tse ruileng ka elektronike hangata ho bolaea li-catalyst, kahoo li-reagents tsa tšepe li ke ke tsa sebelisoa ho haha li-amine tsa thuto e phahameng ho tloha ho li-amine tsa bobeli.M. Christina White le basebetsi-'moho le eena Univesithing ea Illinois Urbana-Champaign ba ile ba hlokomela hore ba ka rarolla bothata bona haeba ba ka eketsa linoko tse letsoai ho risepe ea bona ea react.Ka ho fetola li-amine tsa bobeli hore e be matsoai a ammonium, litsebi tsa k'hemistri li fumane hore li ka sebetsana le metsoako ena ka li-terminal olefin, oxidant, le palladium sulfoxide catalyst ho etsa myriad tertiary amines ka lihlopha tse fapaneng tse sebetsang (mohlala o bontšitsoeng).Litsebi tsa k'hemistri li sebelisitse karabelo ho etsa litlhare tsa antipsychotic Abilify le Semap le ho fetola litlhare tse seng li ntse li le teng tseo e leng li-amine tsa bobeli, joalo ka antidepressant Prozac, hore e be li-amine tsa thuto e phahameng, ho bonts'a hore na litsebi tsa k'hemistri li ka etsa litlhare tse ncha joang ho tse teng (Saense 2022, DOI: 10.1126/science.abn8382).
AZAARENES TLHOKOMELISO KHABONE
Leano le bonts'a quinoline N-oxide e fetotsoeng ho N-acylindole.
Selemong sena litsebi tsa k'hemistri li kenyellelitse lethathamong la ho hlophisa limolek'hule, e leng karabelo e etsang liphetoho litsing tsa limolek'hule tse rarahaneng.Mohlala o mong, bafuputsi ba ile ba etsa phetoho e sebelisang khanya le asiti ho khaola k'habone e le 'ngoe ho li-azaarene tse nang le litho tse tšeletseng ka quinoline N-oxides ho etsa N-acylindoles e nang le mehele ea litho tse hlano (mohlala o bontšitsoeng).Boitšoaro bona, bo hlahisitsoeng ke litsebi tsa k'hemistri sehlopheng sa Mark D. Levin Univesithing ea Chicago, bo thehiloe boikutlong bo amanang le lebone la mercury, le ileng la ntša mahlaseli a mangata a maqhubu a khanya.Levin le basebetsi-'moho ba fumane hore ho sebelisa diode e ntšang khanya e hlahisang leseli ho 390 nm ho ba fa taolo e ntle le ho ba lumella ho etsa hore karabelo e be kakaretso ea quinoline N-oxides.Karabelo e ncha e fa baetsi ba limolek'hule mokhoa oa ho lokisa li-cores tsa metsoako e rarahaneng 'me e ka thusa litsebi tsa k'hemik'hale tsa meriana tse batlang ho atolosa lilaebrari tsa bona tsa batho ba sebelisang lithethefatsi (Saense 2022, DOI: 10.1126/science.abo4282).
Nako ea poso: Dec-19-2022